Mastering the Path: Developing Processes for Successful Clinical-Grade mRNA Manufacturing

Unlock the secrets behind the iterative process development that ensures the highest standards of mRNA manufacturing. At Aldevron, our process development workflow can be tailored to reach the needs of client-specific CQA. Join us as we dive for our webinar into two compelling case studies showcasing the remarkable flexibility of our mRNA process development capabilities.

In the first case, discover how we optimized multiple unit ops to achieve a stunning 95% increase in IVT yield and a 50% improvement in the final full-length product (FLP). In the second scenario, we delve through the innovative optimization of a challenging large self-amplifying RNA (saRNA), by merging the IVT and enzymatic capping into a single “one-pot” reaction, we achieved significant enhancements. Additionally, the use of an improved purification method further boosted the final yield and full-length product (FLP) quality.

As the market evolves towards new technologies, longer constructs, and more stringent specifications, these case studies underscore our agility in adapting to client needs and a dynamic market landscape. Join us to learn how Aldevron ensures your GMP material meets the highest quality standards, paving the way for clinical success.