sNLS-SpCas9-sNLS Nuclease

A simple solution from R&D to clinical material

Aldevron provides Research-grade Cas9 nucleases for use in development work as well as standard cGMP products for clinical studies. The concentration for these products is 10 mg/mL, dispensed in the following sizes:

Research-grade: 0.25 mg and 5 mg vials
cGMP: 1 mg and 10 mg vials

Functional Performance

Ready to use for electroporation or transfection
Extensive QC panels aligned at Research-Grade and cGMP product levels
10 mg/mL formulation

Manufacturing and Quality Control

Research-grade to cGMP
Consistent activity and purity across lots

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sNLS-SpCas9-sNLS Nuclease Quality Control Specifications

Purity, RP-HPLC	≥95%
Purity, SDS-PAGE	≥95%
Aggregation	≤5% aggregate
Concentration	10.0 mg/mL +/- 10%
Endotoxin	≤ 10 EU/mg
Residual DNase	< LOQ
Residual RNase	< LOQ
Appearance	Clear, colorless
Residual Host Protein	≤ 200 ng/mL
Residual Host GenomicDNA	< 1% (w/w)
Activity Assay, in vitro	≥80% of uncut reference DNA converted to cleavage products
Bioburden	< 2 CFU/Sample
Mycoplasma	Negative for the presence of Mycoplasma

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Ordering Information

Product	Small Size	Catalog Number	Large Sizes	Catalog Number
SpCas9 Nuclease	0.25MG	9212-0.25MG	5MG	9212-5MG
cGMP-Manufactured Nucleases
SpCas9 Nuclease - GMP	1MG	9211-0.1ML	10MG	9211-1ML

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