Standardized Cell & Gene Therapy Products
Standardized Cell & Gene Therapy Products
You are developing cell and gene therapies that will transform the lives of patients suffering from a variety of differed diseases. Although you would like to deliver these life-altering products quickly, moving products from research to clinical trials and, finally, to commercialization can require rework and cause expensive delays. At Aldevron, we’ve used our nearly 25 years of manufacturing and regulatory experience to create a suite of standardized, stocked products that can create efficiencies and move your project to clinical trials and commercialization more efficiently. Learn how by downloading our whitepaper below.
Explore our standard products, supporting different cell & gene therapy modalities, from research through commercialization and available for custom manufacture at cGMP:
Aldevron provides a one-vendor strategy for preclinical through GMP gene editing nucleases. Our enzymes are engineered to be used in a variety of applications including electroporation, transfection and microinjection. We provide options for research and GMP quality grades, providing a seamless transition from research through clinical stage development and commercialization. Request sample.
| Product | In Stock at Research Grade | In Stock at cGMP Grade | Custom Order at cGMP | DMF |
| SpyFiTM Cas9 Nuclease | X | X | X | |
| From basic research to clinical applications, our SpyFi Cas9 Nuclease delivers greater editing efficiency and reduced off-target effects. | ||||
| SpCas9 Nuclease | X | X | ||
| For use in development work as well as standard GMP products for clinical studies. | ||||
| AsCas12a Nuclease | X | X | ||
Aldevron IVT enzyme products and services meet or exceed quality and performance requirements at every stage of your mRNA therapeutics development. Aldevron offers comprehensive QC testing on each enzyme. An animal origin statement can be provided for IVT enzymes. As requirements become more stringent, Aldevron offers a seamless path from research grade to GMP enzymes.
| Product | In Stock at Research Grade | Custom Order at cGMP |
| 2’-O-Methyltransferase | X | X |
| Guanylyltransferase | X | X |
| Inorganic Pyrophosphatase | X | X |
| Poly(A) Polymerase | X | X |
| Ribonuclease Inhibitor | X | X |
| T7 RNA Polymerase | X | X |
| DNase I | X | X |
Aldevron provides plasmids for rAAV and rLenti vector production with immediate availability to reduce manufacturing costs and eliminate the need to manufacture custom batches while meeting regulatory requirements.
| Product | In Stock at Research Grade | In Stock at GMP-Source® Grade | In Stock at cGMP Grade | Available for Custom Manufacture at cGMP | DMF Filed with FDA | Royalty Free |
| pALD-HELP | X | X | Expected 2022 | X | X | |
| Replaces any rAAV helper plasmid, Kanamycin resistance, Hexon/fiber sequence free, 11.6 kb | ||||||
| pALD-X80 | X | X | X | X | X | |
| Replaces any rAAV helper plasmid, Kanamycin resistance, 18.9 kb | ||||||
| Rep/Cap | X | AAV6 | X | X | ||
| Each rep/cap plasmid contains the gene sequence for AAV serotype 2 replication (rep) protein paired with either serotype 2, 5 or 6 capsid (cap) protein respectively. | ||||||
| pALD-Lenti System | X | * | * | X | ||
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System includes: pALD-LentiEGFP, pALD-VSV-G, pALD-GagPol, pALD-Rev. The system has been optimized and represents the state of the art in lentiviral vector production. *Only pALD-GagPol-K, pALD-Rev-K, pALD-VSV-G-K are stocked at GMP-Source or available as custom manufacture at cGMP. |
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DasherGFP® mRNA encodes an IP-free, fluorescent protein optimized for expression in mammalian cells. It mimics mature mRNA with 5’ Cap 1 structure and 3’ poly(A) tail, and it is ideal for studying transfection and expression using a variety of assays.
Increase the duration and level of antigen expression for a better immune response using self-amplifying RNA technology. Aldevron utilizes a proprietary pDNA backbone to express a single stranded RNA alphavirus that expresses GFP, SEAP, or nLUC reporter enzyme. If the technology is right for you, we can manufacture your custom saRNA.
| Product | Sample Available at Research Grade |
200µg Size Available |
1mg Size Available |
| DasherGFP® mRNA | X | X | X |
| AldGFP saRNA™ | X | X | X |
| AldSEAP saRNA™ | X | X | X |
| AldnLUC saRNA™ | X | X | X |
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