Research Grade
Affordable, high-quality DNA, RNA, or protein
When you are starting a new project, you need to move quickly and minimize investment both financially and in terms of human resources. You may need to test many different target candidates, but quality is important. You don’t want to artificially exclude a promising candidate due to an unexpected impurity in your biologic prep.
Aldevron offers research grade (RG) custom manufacturing and stocked products for a variety of research and pre-clinical applications, providing the quality, competitive price, and rapid turnaround to move your research phase forward quickly.
Whatever custom manufacturing or stocked product you choose, our progressive quality grades are designed to grow with your project, including our for diagnostic use, GMP-Source™ and full cGMP.
Research grade custom manufacturing projects offer:
- Gene synthesis & cloning options
- Growth via shake flask or fermentation (including high-density options)
- Chromatographic purification
- Consistent manufacturing process
- Customizable quality control specifications
- Certificate of Analysis (CoA) or Product Information Sheet (PIS)
All research grade services and products can be smoothly transitioned to higher quality grades including diagnostic, GMP-Source™ and full cGMP, depending on the molecule type.
Custom plasmid preps are available in two formats.
Aldevron Basic Plasmid preps include Maxi (up to 1mg), Mega (up to 4 mg), and Giga (up to 10 mg) preps; which are a great, cost-effective option for early discovery and come with a limited set of QC assays*, that include:
- UV specifications
- Client specified Buffer
- Concentration report
Aldevron Standard Plasmid preps offer either a client-defined quantity deliverable starting at 1mg or a batch deliverable (shake flask – 2L, 5L and 8L, or fermenters – 10L and 30L) and a broad set of standard and optional QC assays.
| Deliverable Type | Scale | QC Bundle Options | Additional Services |
| Aldevron Basic Plasmid Preparation |
|
N/A - UV spec only | Sequencing•, concentration adjustment, archiving |
| Aldevron Standard Plasmid Preparation |
|
Standard QC Standard+ QC Complete QC |
Sequencing•, RG documentation, RCB, clone screening, archiving |
Get a detailed list of assays included in our QC Bundles here.
All preps arrive complete with a Certificate of analysis (CoA). Additional custom RG plasmid manufacturing options include:
- Process development
- Screening for growth optimization and stability
- Cell Banks
- Manufacturing reports
- Smooth transition from research grade to GMP-SourceTM or full cGMP manufacturing
NanoplasmidTM vectors and linearized plasmids are also available at research grade.
Ready to receive a quote for custom RG Plasmids?
In addition, the following stocked plasmid DNA-related products are also available at research grade:
*Sequencing, archiving, and concentration adjustment are available upon request for an additional fee.
•Varies in price based on sequencing length
As your mRNA program matures, you will need increasing quality and quantity. RNA, as a relatively new and hot modality, has its specific challenges, including a rapidly evolving regulatory environment.
Aldevron, a fast mover in the RNA space, has been providing high-quality RNA precursors (linear plasmid DNA templates, in vitro transcription and capping enzymes) and full RNA drug substance since 2017. More recently, we’ve expanded our research grade (and CGMP) custom manufacturing offering to include:
- Linear DNA template production
- RNA drug substance
- RNA drug product
In addition, the following RNA products are available at research grade:
- Enzymes for in vitro transcription, capping and tailing
- Poly(A) containing cloning backbones
- DasherGFP reporter constructs
Contact Us for more information on RG plasmid template for RNA synthesis
Protein manufacturing is highly customized. Your desired protein may require specific construct design, manufacturing processes, analytics, and characterization. Our research grade protein production capabilities range from parallel screening of several constructs through process development optimization, to scale-up manufacturing. Our protein team is equally adept at transferring in existing protocols or developing new processes and methods. With experience producing thousands of proteins, we identify potential risks and engineer a solution to meet your required specifications. We offer the following expression systems:
- Bacterial Cells
- E. Coli strains selected for each project, all common expression strains are available
- Mammalian Cells
- Cell lines include HEK293, CHO-S, and others by request
- Adherent Cell lines and others upon request
In addition to our custom protein manufacturing, the following stocked products are also available at research grade:
Contact Us for more information on RG plasmid for Protein expression
